About - FRONTLINE® Plus

Get tough on adult fleas, ticks, flea eggs and larvae.

FRONTLINE Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long.

Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, FRONTLINE Plus gives you the power to help prevent a flea infestation on your pet.

Ask your vet about the flea and tick protection of FRONTLINE Plus.

With 2 tough killing ingredients, fipronil and (S)-methoprene, FRONTLINE Plus annihilates adult fleas and ticks. Plus, it eradicates the next generation of fleas by eliminating flea eggs and larvae.

We help protect your pet.

Stops flea infestation
Kills adult fleas, ticks, flea eggs and larvae
Prevents all flea stages (eggs, larvae, pupae) from developing
Kills ticks that may transmit diseases
Provides waterproof effectiveness
Offers a mighty killing force for a full 30 days

See how we stack up to the competition.

*Revolution prevents flea eggs from hatching.

^†REVOLUTION is labeled to control a single species of tick (Dermacentor variablis) in dogs. In heavy tick infestations, complete efficacy may not be achieved after the first dose. (REVOLUTION Label).

Long-lasting killing in action.

In a recent study, it was shown that the powerful ingredients of FRONTLINE Plus work to kill adult fleas within 12 hours of application.¹ They then go on to break the flea life cycle by destroying the next generation of fleas.

Its long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days.

FRONTLINE Plus is stored under the pet’s skin to give non-stop protection for 30 days.

We're the vet's #1 choice.²

We're the vet's #1 choice.¹

Vets prefer FRONTLINE Plus to help protect your pet. After all, it:

Kills adult fleas and ticks
Decimates flea eggs and larvae
Prevents all flea stages (eggs, larvae, pupae) from developing
Works non-stop for a full 30 days

Beyond Killing Fleas and Ticks

See our family of products designed to help protect your pet.

FRONTLINE Plus is just one of the many MERIAL^® products that help you care for your dog or cat.

Find Out More

Learn More About:

Take the flea control quiz.

Who's smarter—you or a flea? Test your knowledge and hone your killing skills with our quiz.

Find a veterinarian.

Enter the ZIP code to locate a licensed vet in your area.

Wash in hot water. Dry on a high setting.

To give your pet extra protection from flea eggs and larvae, periodically clean your pet’s bedding. See more tips.

Find a veterinarian.

Enter the ZIP code to locate a licensed vet in your area.

Take the flea control quiz.

Who's smarter—you or a flea? Test your knowledge and hone your killing skills with our quiz.

Find a veterinarian

1. Everett WR, Gross SJ, Tanner PA, Carithers DS. Immediate and residual speed of kill of FRONTLINE Plus (fipronil + (S)-methoprene) against Rdl-homozygous fleas on dogs assessed at twelve, eighteen, and twenty-four hours post-treatment and following subsequent weekly infestations. Intern J Appl Vet Med. 2011;9(2):119-122.

2. Data on file at Merial.

1. Data on file at Merial.